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1.
Article | IMSEAR | ID: sea-216407

ABSTRACT

Introduction: The prevalence of hyperuricemia (HU) and hypouricemia (Hypo-U) is highly variable in different parts of India and there is a lack of data from the Eastern part of Uttar Pradesh. We designed this study in order to know the exact prevalence of HU and Hypo-U. Materials and methods: This is a cross-sectional study conducted in Varanasi. Data were collected from newly onset diabetic patients over a period of 1 year. Results: Among the 312 diabetic patients, 12.5 and 19.23% were found to have HU and Hypo-U, respectively. Hypouricemic diabetic patients are phenotypically different. They are characterized by the female sex, higher glycated hemoglobin A1c (GlyHbA1c), higher estimated glomerular filtration rate (eGFR), lower body mass index (BMI), and less insulin resistance. Conclusion: The prevalence of HU and Hypo-U is high in newly-onset diabetic patients. Hypouricemic diabetic patients are phenotypically different. Hence routine screening of uric acid is essential for proper diagnosis and appropriate treatment of hypouricemic diabetic patients.

2.
Article | IMSEAR | ID: sea-222015

ABSTRACT

Background: Anti-retroviral therapy (ART) for HIV has changed a highly fatal disease to a chronic manageable condition. National technical guidelines by NACO say that adherence of >95%(optimal) is required for optimal viral load suppression which is a challenge both for the patient and the health system. Objectives: This study was conducted to determine the reasons for missed and lost to follow-up (LFU) cases and to assess the impact of the COVID pandemic on ART adherence. Settings and Design: Cross-sectional study conducted at ART center, Jhansi. Methods and Material: 357 patients were administered a self-designed questionnaire after taking informed consent to enquire about the reasons for missing doses and LFU and whether they missed treatment during the lockdown. Statistical analysis used: the results were expressed in frequencies and percentages and appropriate statistical tests were applied. Results: 72% HIV patients had optimal adherence and 6.7% were on second-line treatment. Out of 357 patients, 56 had missed treatment and 10 were LFU. The main reasons for the missing were run out of pills, busy with other things and being away from home. The number of episodes of missed and LFU increased during the pandemic. The main problems faced were lack of transport (24), fear of catching the disease (7), no money to hire a vehicle (5). Conclusions: Constant monitoring and handholding of those with suboptimal adherence is required. Travel allowance to such patients and regular counseling will help to ensure adherence. Long-term solutions include vocational rehabilitation and awareness programs to reduce stigma and discrimination.

3.
Article | IMSEAR | ID: sea-222011

ABSTRACT

Background: Countries around the world are now racing to vaccinate people against SARS-CoV-2, the virus that causes COVID-19. The Government of India also rolled out its vaccination drive from 16th January ‘2021. Aims: To estimate the antibody response of the COVID-19 vaccine in the form of SARS-COV-2 IgG antibodies in vaccinated healthcare workers. Methods: Prospective follow-up was study conducted on healthcare workers (HCWs) of a Medical college in Dehradun, Uttarakhand. Healthcare workers who have been vaccinated for COVID-19 were tested for SARS-CoV-2-IgG antibodies at regular intervals i.e at 4 weeks after the 1st dose and then again at 4 weeks after the 2nd dose. The third sample was taken 6 months after the 2nd dose. Results: A total of 302 HCWs were enrolled in the study who gave their samples for IgG antibody estimation after the Covishield vaccine. After 4 weeks of completion of both doses, 96% HCWs formed SARS-COV-2 IgG antibodies, whereas 4% didn’t. Then after 6 months of follow-up, 14% HCWs have become negative for antibodies and better immunity is seen in people who also got infected with COVID-19 during this time. Conclusion: This study concludes that the immunity gained after vaccination is waning off in around 6 months and there is a need for a booster dose, especially for people at high risk. The infection control practices still play a crucial role in the prevention of this deadly disease.

4.
Article | IMSEAR | ID: sea-222007

ABSTRACT

Background: The estimation of gender using hand dimensions is a crucial role in forensic investigation and legal sciences. Objectives: In this study, the mean score of hand measurements have been derived and linear discriminant analysis has been applied to predict gender from hand dimensions. An Independent t-test has been employed to know discrimination between male and female. The accuracy of gender estimation has been derived and checked by ROC curve. Material and Methods: A sample of 150 participants has been collected for the completion of this study, where 78 males and 72 females were found aged between 18 and 24 years. The breadths and lengths of left and right hands of the participants have been measured. Results: Respondents’ mean score of length and breadth of left hand were found 17.69 ± 1.30 and 7.56 ± 1.17, respectively. It was found to be significantly different in the respondents’ mean scores of males and females. Conclusions: The hand dimensions of males were higher than females. The prediction of a number of females and males were 76 and 74, respectively, and its accuracy was observed 0.87. This research can be applied for larger sample and would be helpful in predicting gender discrimination among adults through hand dimensions.

5.
Article | IMSEAR | ID: sea-217937

ABSTRACT

Background: A physically active lifestyle is the cornerstone of good health. A sedentary lifestyle is emerging as a global threat to public health and physical activity is being recommended as an important intervention for the prevention and control of non-communicable diseases. Aim and Objectives: The present study aims to assess the level of physical activity and duration of sitting time among medical undergraduates to guide the formulation of strategies for healthy lifestyles. Material and Methods: A cross-sectional study was conducted among medical undergraduate students of a teaching hospital in North India. Data were collected using a structured questionnaire regarding the demographic profile, anthropometric parameters, physical activity, and sitting time. The level of physical activity and time spent sitting was assessed using International Physical Activity Questionnaire. R software was used for data analysis. Results: A total of 250 medical students were included with a response rate of 83.3%. Overall, 67.6% of students engaged in moderate levels of physical activity, 21.2% engaged in high levels, and 11.2% engaged in low levels of physical activity. The mean time spent sitting was 8.8 hours/day (males: 8.5 and females: 9.1). It showed a significant association between physical activity and body mass index, with the low prevalence of obesity among students engaged in moderate and high levels of physical activity. Conclusion: The study highlights prolonged sitting as an emerging public health problem where three-fourths of students were spending more than 7 hours/day sitting. However, the majority of students were engaged in moderate to high levels of physical activity.

6.
Article | IMSEAR | ID: sea-221836

ABSTRACT

Introduction: Cases of undiagnosed exudative pleural effusions are common in clinical practice and pose a diagnostic challenge for pulmonologists. Medical thoracoscopy allows both direct visualizations of pleural space for diagnostic evaluation and chemical pleurodesis for therapeutic purposes. Objectives: This study investigated the diagnostic role of medical thoracoscopy in the cases of undiagnosed exudative pleural effusions and complications of thoracoscopic pleural biopsy. Patients and methods: Between December 2016 and August 2019, 195 patients of undiagnosed exudative pleural effusions underwent medical thoracoscopy in our institute. Pleural biopsies were taken and sent for histopathological and microbiological examination. Results: The diagnostic yield of medical thoracoscopy in this study was 89.7%. Definite diagnosis was achieved in 175 out of 195 patients of the study population and only 20 (10.3%) patients were failed to be diagnosed by medical thoracoscopy. Histopathological results of thoracoscopic pleural biopsy among the study population revealed tubercular pleuritis in 31.79% (62 patients), metastatic adenocarcinoma in 23.07% (45 patients), malignant mesothelioma in 18.46% (36 patients), parapneumonic effusions in 6.66% (13 patients), metastatic squamous cell carcinoma in 5.64% (11 patients), small cell carcinoma in 3.07% (6 patients), malignant lymphoma in 0.51% (1 patient), and rheumatoid pleuritis in 0.51% (1 patient). Only 19.4% (38 patients) had minor complications like pain, minor bleeding, subcutaneous emphysema, and re-expansion pulmonary edema. Conclusion: Thoracoscopy is a safe, well-tolerated procedure with minimal risk allowing the accurate diagnosis of undiagnosed pleural effusion. Besides determining the underlying cause, it also provides unique therapeutic approaches like pleurodesis to patients with malignant pleural effusions.

7.
Article | IMSEAR | ID: sea-217837

ABSTRACT

Background: From the past few decades, disturbed sleep pattern has grown to be a hallmark of modern-day society among the adolescents and in adults. Both are having disturbed sleep patterns with average sleep duration of 7 h per night. Smartphones, tablets, and television which are the remarkable source of information and entertainment have robbed sleep time and have led to voluntary sleep restriction as self-reported by them and it has become a serious barrier to health development. Along with-it, high blood pressure (BP) levels are influenced by high body mass index (BMI) and low cardiorespiratory fitness which are among the most important cardiovascular disease risk factors. However, how sleep attenuates the individuals BMI, cardiorespiratory fitness and BP in adolescents are uncertain. Aims and Objectives: The aim of this study was to analyze whether the disturbed sleep pattern is a mediator between body composition, Cardiorespiratory fitness (CRF), and BP levels in young adolescents. Materials and Methods: This study was a cross-sectional study which involved students of MMIMSR (n = 500), of which 250 male and 250 female participants were recruited. Initial explanation about the aim and purpose of the study, test procedure, method of testing, and instruction of how to perform the test was given. All the participants were examined under similar laboratory conditions. Detailed history with thorough clinical examination were done. All basal parameters such as heart rate, BP, and respiratory rate were also measured. Results: In our study, disturbed sleep patterns were highly significantly (P < 0.01) associated with high BMI which acted as a mediator between low CRF and high BP in both the participants. Our results highlighted the importance of a sleep in maintaining a healthy lifestyle, CRF and to prevent hypertension in young adolescents. Conclusion: The findings of our study are consistent with the hypothesis that disturbed sleep might be one of the reasons which influence BMI and long-term cardiovascular health.

8.
Article | IMSEAR | ID: sea-217801

ABSTRACT

Background: Chronic kidney disease (CKD) exists both as a common cause of hypertension and also a complication of uncontrolled hypertension. This complex interplay of hypertension and CKD further increases the risk of adverse cardiovascular and cerebrovascular outcomes in patients with compromised renal function. Aim and Objectives: The present study tried analyze the characteristics of hypertensive CKD patients and the current antihypertensive treatment pattern in CKD patients in a tertiary care set up in Eastern India. Materials and Methods: A prospective and observational study included adult currently diagnosed CKD patients along with hypertension. Basic demographics along with medical history, blood pressure (BP) measures treatment details, and laboratory information were retrieved for each included patient, noted and analyzed statistically. Results: Around 47% patients were taking two antihypertensives, followed by 19.7% on three and 17.97% on one antihypertensive, respectively, and over 50% patients demonstrating high normal BP, followed by 25% having Grade I hypertension and around 20% having Grade II hypertension. Various classes of antihypertensives prescribed in the present study included calcium channel blockers, beta-blockers, angiotensin receptor blocker, angiotensin-converting enzyme (ACE) inhibitors, centrally acting drugs, alpha-blockers, and diuretics. Beta-blockers were found to be the most prescribed antihypertensives, being prescribed in 92.69% CKD patients. This was followed by calcium channel blockers, centrally acting drugs, alpha-blockers, angiotensin receptor blocker, diuretics, and ACE inhibitor. Utilization pattern of antihypertensive drugs among CKD patients helps with a better glimpse on the status of BP control and related renal outcomes in hypertensive CKD patients. Conclusion: Considering the interplay of hypertension and CKD, it is imperative to essentially treat hypertension robustly to ensure better cardio and renoprotection in these CKD patients. Utilization pattern of antihypertensive drugs among CKD patients helps with a better glimpse on the status of BP control and related renal outcomes in such patients. A rational multidrug antihypertensive regime can help achieve better patient outcomes in hypertensive CKD patients.

9.
Article | IMSEAR | ID: sea-217351

ABSTRACT

Background: Antibiotics act as a therapeutic weapon in eradicating pathogens. Antibiotics are the most common group of drugs misused for self-medication. This is a global public health concern and is one of the major contributing factors to antibiotic resistance (ABR). This study aimed to assess the knowledge and beliefs of the public in Qatar regarding appropriate antibiotic use and antimicrobial resistance. Methods: A cross-sectional research design was used to collect the information from the participants based on an adapted questionnaire from the Centers for Disease Control and Prevention (CDC) and the World Health Organization (WHO) between September – November 2018. The study enrolled 1000 par-ticipants who visited two large emergency departments (ED) of public hospitals in Qatar. Results: The mean knowledge and belief scores were 55.07±15.87 and 66.57±23.13 respectively. 42% of the participants had moderate knowledge regarding antibiotic and antimicrobial resistance. The majori-ty of the participants (64.8%) believed that antibiotics fight against bacteria and viruses. The educational level significantly influences the belief of the participants. Graduates possess a higher belief score of 11.75±12.5 (P=0.001) compared to others. Conclusion: The key findings of this study highlighted the existing gap in knowledge among the public. A community-based health education program should be launched to promote judicious of use antibiotics

10.
Indian J Pathol Microbiol ; 2022 Sept; 65(3): 630-636
Article | IMSEAR | ID: sea-223310

ABSTRACT

Context: Many standard books, literatures, and internet described the characteristic lineament of each salivary gland lesion. Nevertheless, there are dozens of disarray, confusion, and unmanageable morphological features regarding proper reporting. To fight with these issues, Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) was introduced in 2018, but still the third category, Atypia of undetermined significance (AUS), poses difficulties for the pathologists and clinicians for a definite interpretation. Aim: The aim is to analyze the risk of neoplasia (RON) and risk of malignancy (ROM) of Milan's category III (AUS) by subdividing into six groups based on cytolomorphology. Settings and Design: The duration of study was from March 2018 to may 2021 with the focus on ROM and RON of all Milan's categories with especial attention on AUS. Methods and Material: Result of total 329 Fine Needle Aspiration Cytology of salivary glands was categorized according to MSRSGC. On the basis of cytomorphology, further subtyping of AUS and its cytohistopathology correlation was done. The ROM and RON of each subtype was analyzed. Statistical Analysis: All data were calculated by existing formulas. Results: Out of 329 aspirates, 24 (07.29%) cases belong to AUS with availability of histology in 13 (54.17%) cases. RON and ROM was 84.62% and 53.85%, respectively. Cases of lymphocytes with nuclear atypia (L-NA) was the most prevalent (29.17%). The RON were 60.00%, 68.57,% 84.62%, 94.87%, 87.50%, 100%, 100% and the ROM were 20.00%, 11.42%, 53.85%, 05.13%, 43.75%, 83.33% and 100% in each Milan's categories I, II, III, IVa, IVb, V, and VI, respectively. ROM was the highest in cystic fluid with nuclear atypia (C-NA) (100.0%), followed by basaloid cells (75%), L-NA (66.675), and SC (50%), but ROM was zero in NA and oncocytic cells. Conclusions: Subgrouping of AUS helps to dissipate the muddiness and provide more exact and reproducible diagnostic and prognostic tool.

11.
Article | IMSEAR | ID: sea-221973

ABSTRACT

Background: Anthropometry is widely used for Identification of an individual. Height is one of the most important parameters of anthropometry. It is strongly correlated with the individual’s hand dimensions and if either of the measurements are known, the other can be calculated. Aim and Objective: To know correlation between the hand dimensions and Height of an individual and to apply the regression line of height on hand dimension of the person. Methods and Material: A crosssectional study was conducted among the medical students. Anthropometric indices were recorded after obtaining written consent and institutional approval using standard equipments. Linear regression and Pearson coefficient were calculated to study the correlation and arrive at the equation to calculate Height from Hand length. Results: Age of the study participants who consented for study (150) ranged between 18-24 years. Mean height was 165.91 cm. Mean right hand length was 17.71 cm and 17.69 cm on left hand. Mean hand width was 7.79 cm on right side and 7.56 cm on left side. A statistically significant positive correlation was observed between height and the hand dimensions. Conclusions: There was a statistically significant positive correlation between hand dimensions and height. Forensic investigation, body identification and triage can be facilitated through calculating Height from hand dimensions when only mutilated body remains are received during disasters.

12.
Indian J Prev Soc Med ; 2022 Jun; 53(2): 78-83
Article | IMSEAR | ID: sea-223997

ABSTRACT

Background: COVID-19 was declared pandemic by WHO on 30th January 2020 and to cure it, No specific antiviral treatment has been developed yet, therefore only preventive measures such as; facemask, regular hand washing, social as well as physical distancing, respiratory etiquettes and vaccination against Covid-19, are proven methods of its control and prevention. Objectives: To study the knowledge, Attitude and Practices among people about COVID-19 vaccine and find out various socio-demographic factors for its decision making. Material &Methods: A descriptive cross sectional study was conducted among the persons attended the tertiary care center to get vaccine against COVID-19 at Government Medical College, Badaun, UP. Results: Out of all respondents, majority (77.2%) of them accepted to get the vaccine as soon as available. 81.5% of respondents were male and more than half (60%) of them were unmarried. More than three fourth (77.5%) of respondents were unemployed and nearly one third (32%) belonged to BPL category. As per study, majority of respondents (86%) and (71.8%) said that vaccine is safe and effective way to control and prevent COVID-19, respectively.(77.2%)respondents who accepted that vaccine should be taken as soon as available, more than half (57%) of them said that doctor's recommendation is an important factor in vaccination decision-making.Conclusion: The most important factor for vaccine hesitancy is the occurrence of mild to moderate adverse effects following immunization, and this may be the biggest challenge in the global response against the Covid-19 pandemic.

13.
Article | IMSEAR | ID: sea-217578

ABSTRACT

Background: During MBBS course, the students’ study about cardiovascular system (CVS) in physiology, pathology, pharmacology, preventive medicine, pediatrics, and medicine for the management and diagnosis of cardiovascular disorders. Blood pressure measurement is a common and a beneficial tool for the diagnosis of cardiovascular disorders (hypertension, hypotension, etc.) along with their treatment and management. Thus, knowing the proper technique of measuring blood pressure becomes an essential part of learning the course and management of cardiovascular disease. This study is designed to teach and train the first phase undergraduate students to measure blood pressure in a proper way so that they do not stumble on the first step of examination of CVS. Competency-based training is an outcome-based approach that involves identifying the skills acquired by Indian medical graduate. Competency-based teaching involves teaching of undergraduate students to support their achievement and assessment of the communication and technical skills and to develop their ability to interpret the results of blood pressure measurement for apt patient management. Aim and Objectives: This study aims to assess and compare the effect of competency-based teaching and traditional teaching in learning the skill of blood pressure measurement. Materials and Methods: Two hundred students were taken from Phase I undergraduate medical students which were randomly divided in two Groups A and B. Competency-based teaching of blood pressure measurement was done in Group A in by teaching method of demonstrate, observe, assist, and perform and Group B was taught by traditional demonstration. Pre-test questionnaire was given to both the groups before beginning of the practical session. The students learning of skill to measure blood pressure was assessed by directly observed procedural skills (DOPS) checklist after which student feedback was provided along with filling up of the post-test questionnaire. Furthermore, feedback from both student and teacher was collected. Results: Highly significant difference was found between pre-test and post-test of both Group A and Group B. Significant difference was found between Group A and Group B post-test scores. It was found that Group A in which competency-based teaching was done scored higher post-test scores then Group B. Furthermore, highly significant difference was seen among the scores of DOPS checklist between Group A and Group B. Conclusion: In the present research study, it was found that the students who underwent competency-based training of the skill of blood pressure measurement showed significantly higher scores in learning and performing the skill. Furthermore, on feedback provided by the students, 96% of the students strongly agree that the competency-based teaching and learning is better than traditional teaching.

14.
Indian J Prev Soc Med ; 2022 Mar; 53(1): 48-57
Article | IMSEAR | ID: sea-224034

ABSTRACT

Background: Inadequate knowledge of advance, absence of exact health data, and the prohibitions associated with sex education at homes and schools, indulgence in risky behavior and a lack of access to adequate reproductive health services further lends the adolescents susceptible to AIDS. Aim & Objectives: In the present study, the knowledge and behavior towards HIV/AIDS among students in selected school have been assessed. Material & Methods: Primary data has been taken from selected school with the help of structured questionnaire tools; school is located at Bhaipur Brahman village in Jewar block of Gautam Budh Nagar district, India. Univariate and Bivariate tables as well as chi-square test have been applied to know the association between demographic variables of students and their response. Results: It was found that more than 65 % students were aware about HIV/AIDS. About 31% of students were reported that it cannot be transmit through sharing syringes where equal responses have been observed by male and female students. Conclusions: It was observed that they had inadequate knowledge towards HIV/AIDS especially among age group10-13 years. Most of them have good attitude towards HIV/AIDS infected person.

15.
Malaysian Orthopaedic Journal ; : 71-77, 2021.
Article in English | WPRIM | ID: wpr-923061

ABSTRACT

@#Introduction: Pre-operative identification of patients with inadequate hamstring graft for anterior cruciate ligament reconstruction is still a subject of interest. The purpose of this study is to correlate dimension of a harvested dimensions graft with patient physical anthropometric variables. Materials and methods: This cohort study included 280 patients (male = 226, female = 54) scheduled for primary anterior cruciate ligament (ACL) reconstruction. Interrelationships between quadruple semitendinosus (ST) graft and anthropometric parameters (age, sex, height, weight, and BMI) were assessed using Pearson Correlation test and regression analysis. Difference among gender was analysed using Mann Whitney and t test. The observed graft diameter was also compared with the literature using Bland – Altman plot. Results: Mean age of cohort was 29 years (range, 17-50 years), mean height was 1.69m (range, 1.6-1.9m), mean weight was 75 kg (range, 50-116kg) and mean BMI was 26kg/m2 (range 16.65-40.40kg/m2). Mean quadruple length of harvested ST graft was 7cm (7.1±0.6 cm, range, 5.6- 8.8cm) and mean diameter was 8mm (8.2±0.8mm, range, 6.5-10mm). Only height and weight were significantly correlated with graft length and diameter in both sex (p value <0.05). Female, compared to male, had significantly smaller (p<0.0001) and thinner graft (p<0.0001). There was a strong agreement between the literature and our observed graft diameter, but with an overestimated graft diameter in 18.5% of the cases. Conclusion: Among anthropometric parameter, only height and weight had moderate positive correlation with graft diameter. Males had longer and wider ST graft in contrast to age-matched female group.

16.
Int J Pharm Pharm Sci ; 2020 Aug; 12(8): 111-116
Article | IMSEAR | ID: sea-206006

ABSTRACT

Objective: The objective of the present study is the evaluation of the effect of the sublethal (40% and 60% of 48h LC50) binary combination (1:5 ratios) of molluscicides deltamethrin+MGK-264 on the endogenous levels of protein, amino acid and nucleic acid in different tissues of snail Lymnaea acuminata. Methods: The snails were treated with 1:5 mixtures of sub-lethal concentration of (40% and 60% of 48h LC50) deltamethrin+MGK-264 on the protein, amino acid and nucleic acid levels in gonadal, nervous and foot tissue of L. acuminata. In order to study the effect of withdrawal from treatment, the snails were first exposed to the above concentrations for 96h, after which they were transferred to freshwater. Water was changed every 24h for the next seven days, after which different biochemical parameters were estimated. Results: There was a significant change in the levels of protein (sublethal concentration of 60% of 48h LC50 after 96h) gonadal, nervous and foot tissues are 48.1, 12.1 and 14.5%, respectively, amino acid are 273, 234 and 252%, respectively, DNA are 25.1, 38.9 and 42.1%, respectively and RNA are 12.2, 30.7 and 30.5%, respectively. These changes were time and concentration-dependent. In the withdrawal experiment, the snails were treated for 96h to transfer in freshwater for 7 d, which caused significant recovery in all the biochemical parameters. Conclusion: The present study concluded that the high molluscicidal activity of deltamethrin+MGK-264 simultaneous decrease in the levels of proteins, DNA, RNA and increase in the level of amino acids.

17.
J Environ Biol ; 2020 Jul; 41(4): 796-802
Article | IMSEAR | ID: sea-214545

ABSTRACT

Aim: The present study was aimed to understand the prevalence of heifer mastitis and its associated risk factors in Jammu region.Methodology: A total of 250 pregnant heifers (1000 quarters) were screened, and lacteal secretions were collected from 915 quarters individually, in order to estimate the prevalence of heifers mastitis by culturing. The prevalence was estimated based on the results of microorganism culture. Results: The overall prevalence of heifer mastitis was 90.80% by cultural examination whereas only 30% of the animals produced clinical signs. The prevalence was higher in organized management system and prime risk factors associated with mastitis were season of calving, prepartum intra-mammary infections, poor udder hygiene, etc., in both organized and unorganized managements. Interpretation: High pre-valence of heifer mastitis (as evidenced by presence of microorganisms) is alarming situation for dairy farming in India. Season of calving, milk leakage at calving, prepartum IMI, poor udder hygiene, sanitation, beddings, floor type, and contact of heifers with older cows could be the important risk factors.

18.
Article | IMSEAR | ID: sea-210917

ABSTRACT

Present study was undertaken to study the neurotoxicity of oral acrylamide (ACR) and its amelioration using α-tocopherol, reduced glutathione (GSH) and hot aqueous extract (HAE) of Ocimum sanctum. Forty five male Wistar rats were divided into 12 groups. The study showed a significant reduction in the body weight of the rats fed with ACR in comparison to the other groups while body weight was restored in the rats fed with α-tocopherol and HAE. Neurotoxicity in rats fed with ACR was evident with the results of histopathology and oxidative stress (high MDA and decreased activities of GSH, SOD, GST and CAT in brain). Co-administration of α-tocopherol and HAE lowered these changes however, there was no marked improvement seen in neural damage but improvement was evident in behavioral as well as physiological changes at a marked point. Histopathology of brain in ACR alone fed group showed extensive neural degeneration and massive deposition of fibrin which was substantially decreased and ameliorated with the co-administration of α-tocopherol and HAE. These results support the oxidative stress results as well. Our results suggests that α-tocopherol and HAE can be useful for protecting brain tissue against ACR induced neurotoxicity through minimizing the free radical mediated oxidative stress

19.
J Environ Biol ; 2020 Mar; 41(2): 234-239
Article | IMSEAR | ID: sea-214499

ABSTRACT

Aim: A study was conducted to develop a new approach of non-stress baseline and evaluate different approach of determining non stress baseline for Crop Water Stress Index (CWSI).Methodology: To observe maximum and minimum canopy temperature, two plots with three replications were maintained at fully stress (no irrigation) and no stress (fully irrigated) conditions, respectively. Portable weather station with data logger was installed at the middle of field to record continuous data at half an hour interval. Gypsum block soil moisture sensor were buried at 20 cm interval up to 100 cm and connected with data logger. Infrared radiometer was used to measure canopy temperature. Results: The evaluation was based on five statistical indicators; correlation coefficient (R2), root mean square error (RMSE), mean absolute error (MAE), mean bias error (MBE) and Wilmot index of agreement (d). It was found that new regression base line performed better than other existing approaches. The calculated value of RMSE, MAE, MBE, d and R2 were 0.65, 0.51, 0.02, 0.79 and 0.83, respectively, for new baseline approach. Interpretation: The newly developed multiple regression equation (incorporating three weather parameters (Rn, VPD and u) and two crop growth parameters (h and CC)) helped to reduce error in the calculation of non-stress baseline for wheat crop in humid subtropical climate

20.
Article | IMSEAR | ID: sea-204851

ABSTRACT

The impacts of climate change on water quality of water bodies are associated with the climatic extreme events (heavy rainfall and flood, heat, drought, wildfires, cyclones, hurricane, super storms) as the major drivers that require knowledge of understanding. Most research studies present the role of climate change in threatening water quality, risks on drinking water and contributions of catchment in water pollution, but less attention has directed to specific sensitive water quality parameters, appropriate methodologies, risks on ecosystem and managerial practice to reduce the impacts. This review highlight the of effect climate change on surface water bodies based on recent literatures on the impacts of climate change on water quality and promote practical opportunity for better management of these impacts. We conclude that consideration of climate change preparedness plan in catchments is the best option to adopt for minimization of climate change impacts on water quality of water bodies.

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